Bupropion has been extensively studied and approved by the FDA for treating several conditions.

Major Depressive Disorder

Bupropion is considered a first-line treatment for depression, with research showing that people with depression experience significant improvement when taking this medication. It may be particularly effective for people experiencing depression with fatigue, low energy, or difficulty concentrating.

Seasonal Affective Disorder (SAD)

Under the brand name Wellbutrin XL, bupropion is specifically approved for preventing seasonal affective disorder, a type of depression that occurs during fall and winter months when daylight is reduced.

Smoking Cessation

Under the brand name Zyban, bupropion is FDA-approved to help people quit smoking. Studies show that bupropion can significantly increase the likelihood of successfully quitting tobacco use by reducing cravings and withdrawal symptoms.

Off-Label Uses

Healthcare providers may also prescribe bupropion for conditions not officially FDA-approved, including:

• Attention-deficit/hyperactivity disorder (ADHD)

• Anxiety disorders (though typically not first-line)

• Bipolar depression (with mood stabilizers)

• Sexual dysfunction caused by SSRIs

• Weight management